Blistering diseases (AMBDs) are a group of conditions that manifest with blisters on the skin or mucous membranes. In order to get the most accurate diagnosis when performing biopsies in AMBD, the tissue for hematoxylin and eosin (H&E) should be taken from the edge of a blister and the sample for direct immunofluorescence (DIF) should be taken from perilesional skin.
Blistering diseases are a heterogeneous group of disorders that can affect either skin and mucous membrane, or both, varying in presentation, clinical course, pathohistology, immunopathology and treatment. Not infrequently the diagnosis is delayed. This can result in severe, and sometimes fatal consequences. Although these diseases are rare, it is very important to make an accurate diagnosis based on a combination of clinical profile and laboratory observations. A brief review is presented of the following bullous diseases: pemphigus, paraneoplastic pemphigus, bullous pemphigoid, cicatricial pemphigoid, epidermolysis bullosa acquisita, dermatitis herpetiformis, linear IgA bullous disease, porphyria cutanea tarda, and subcorneal pustular dermatitis.